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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T4359 | VAS2870 | NADPH | |
VAS2870 is an inhibitor of NADPH oxidase (NOX). | |||
T8107 | GLX351322 | NADPH-oxidase , NADPH | |
GLX351322 is NADPH Oxidase 4 Inhibitor with IC50 of 5 μM. | |||
T8408 | GKT136901 | AK120765 | NADPH-oxidase , NADPH |
GKT136901 (AK120765) is an inhibitor of NOX1/4.It acts as Selective and Direct Scavenger of Peroxynitrite | |||
T7042 | 1,5-Isoquinolinediol | PARP | |
1, 5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC50: 0.39 μM). The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1, 5-Isoquinolinediol... | |||
T15433 | GSK2795039 | Apoptosis , Reactive Oxygen Species , ROS , NADPH | |
GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 decreases apoptosis. GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) (pIC50: 6 in different cell-free assays). | |||
T6099 | Setanaxib | GKT137831 | NADPH-oxidase , Ferroptosis , NADPH |
Setanaxib (GKT137831) is a potent, specific dual NADPH oxidase (NOX1/4) inhibitor. | |||
T22990 | ML-090 | Fluoflavine | NADPH-oxidase , Others |
ML-090 is NOX1-specific inhibitor(IC50 = 90 nM) which is >100 selectivity for NOX1 over NOX2, NOX3, NOX4 (all IC50s >10 μM). | |||
T7191 | Diphenyleneiodonium chloride | DPI | NOS , Reactive Oxygen Species , NADPH , TRP/TRPV Channel |
Diphenyleneiodonium chloride (DPI)(DPI) is an irreversible inhibitor of iNOS and eNOS (IC50 values of 50 nM and 0.3 μM, respectively),and displays broad-spectrum bactericidal activity. | |||
T10353 | APX-115 free base | Ewha-18278 free base | NADPH-oxidase , NADPH |
APX-115 free base (Ewha-18278 free base) (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor (Kis: 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4). APX-115 effectively prevents kid... | |||
T38423 | CL097 | CL097 | Reactive Oxygen Species , TLR |
CL097 is an effective agonist of TLR7 and TLR8. CL097 induces pro-inflammatory cytokines in macrophages and NADPH oxidase priming, thereby increasing the fMLF-stimulated ROS production. | |||
T83625 | INOS-IN-14 | 3-bromo-1H-indazole-7-carbonitrile | NOS |
iNOS-IN-14 (3-bromo-1H-indazole-7-carbonitrile) is a potent nitric oxide synthase (NOS) inhibitor that inhibits the NADPH oxidase activity of nNOS. | |||
T29097 | VAS 3947 | VA-S3947,VA S3947,VAS3947 | Apoptosis , NADPH-oxidase |
VAS 3947 is a specific inhibitor of NADPH oxidase (NOX).VAS 3947 has a potent anti-platelet effect, inducing apoptosis through UPR activation, mainly due to protein aggregation and misfolding, independent of anti-NOX act... | |||
TP1886L1 | NoxA1ds acetate(1435893-78-9 free base) | NADPH-oxidase | |
NoxA1ds acetate is a potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 : 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. Inhibits NOX1-derived O2- production in HT-29 human col... | |||
T38404 | MJ33 lithium salt | ROS | |
MJ33 lithium salt is an inhibitor of NADPH oxidase type 2-mediated ROS generation, a fluorinated phospholipid analog that inhibits the phospholipase A2 (PLA2) activity of peroxiredoxin 6 (Prdx6), and is used in the study... | |||
T22096 | L 012 sodium salt | ||
L 012 sodium salt, a luminol analogue, is a widely used chemiluminescent (CL) probe for active oxygen and active nitrogen. L 012 sodium salt is widely used to detect the superoxides (O2•−) derived from NADPH oxidase (Nox... | |||
T15300 | Fluorofenidone | AKF-PD | Others |
Fluorofenidone (AKF-PD) attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway. Fluorofenidone is an an... | |||
T10354 | APX-115 | Ewha-18278 | NADPH-oxidase |
APX-115 (Ewha-18278) (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor (Kis: 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4). APX-115 effectively prevents kidney injury. | |||
T14021 | 20-HETE | 20-hydroxy Arachidonic Acid | Others |
20-HETE (20-hydroxy Arachidonic Acid) is a CYP450 metabolite and a potent vasoconstrictor and it is an endogenous inhibitor of the large-conductance Ca2+-activated K+ channel in renal arterioles. 20-HETE increases NADPH ... | |||
T13112 | Tat-NR2B9c | Tat-NR2Bct,NA-1 | NO Synthase , iGluR |
Tat-NR2B9c (NA-1) is a postsynaptic density-95 (PSD-95) inhibitor with neuroprotective and antiepileptic effects.Tat-NR2B9c inhibits PSD-95d2, PSD-95d1, and PSD-95, which prevents the activation of NMDA-induced NADPH oxi... | |||
T0825 | Ebselen | SPI-1005,PZ-51,CCG-39161 | Phosphatase , Virus Protease , Calcium Channel , COX , HIV Protease |
Ebselen (CCG-39161) is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is thereby able to prevent cellular damage induced b... | |||
T12781 | RV01 | Others | |
RV01 is a novel quinoline-substituted analogue of resveratrol that inhibits DNA damage, reduces ethanol-induced acetaldehyde dehydrogenase (ALDH2) mRNA expression, and has hydroxyl radical scavenging activity. rV01 reduc... | |||
T69630 | Diphenyleneiodonium (free base) | ||
Diphenyleneiodonium (free base) is an NADPH oxidase inhibitor. | |||
T71513 | GK-136901 | ||
GK-136901 is a first-in-class, potent, and orally bioavailable NADPH oxidase isoform 4 (Nox4) inhibitor. | |||
T80243 | Gp91 ds-tat | ||
Gp91phox ds-tat, a biologically active peptide, functions as an inhibitor of NADPH oxidase assembly. | |||
T78592 | Diapocynin | Dehydrodiacetovanillone | |
Diapocynin (Dehydrodiacetovanillone), a dimer of Apocynin, acts as an orally administered inhibitor of NADPH oxidase. It exhibits anti-inflammatory, neuroprotective, and antioxidant properties [1]. | |||
T75813 | Ac9-25 TFA | ||
Ac9-25 TFA, an N-terminal peptide of Annexin I, functions as a formyl peptide receptor (FPR) agonist, activating neutrophil NADPH oxidase via FPR [1] [2]. | |||
T11333 | Fulvene-5 | Others | |
TP1886 | NoxA1ds | ||
Potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 = 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. Inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. Atte... | |||
TP2083 | Ac9-25 | ||
N-terminal peptide of Annexin I (AI/Lipocortin I) that inhibits leukocyte extravasation. Acts as a formyl peptide receptor 1 (FPR1) ligand and stimulates neutrophil NADPH oxidase activation. | |||
T75949 | NoxA1ds TFA | ||
NoxA1ds TFA is a potent and selective inhibitor of NADPH oxidase 1 (NOX1), with an inhibition concentration (IC50) of 20 nM, demonstrating selectivity over NOX2, NOX4, NOX5, and xanthine oxidase. It effectively inhibits ... | |||
T60517 | CL097 hydrochloride | ||
CL097 hydrochloride is a potent TLR7 and TLR8 agonist. CL097 hydrochloride induces pro-inflammatory cytokines in macrophages and NADPH oxidase priming, thereby increasing the fMLF-stimulated ROS production [2]. | |||
T35393 | Gp91ds-tat | gp91ds-tat | NADPH-oxidase |
gp91ds-tat is a useful organic compound for research related to life sciences and the catalog number is T35393. | |||
TP1585 | Sgp91 ds-tat Peptide 2, scrambled | ||
This peptide is a scrambled sequence of NADPH oxidase assembly peptide inhibitor gp91 ds-tat. It is used as a control peptide. It is two amino acid residues shorter at the N-terminus compared to the scrambled gp91 ds-tat... | |||
T38646 | GKT136901 hydrochloride | GKT136901 hydrochloride | |
GKT136901 hydrochloride is a powerful, selective, and orally active inhibitor of NADPH oxidase (NOX1/4). It exhibits K i values of 160 nM and 165 nM against NOX1 and NOX4, respectively. Additionally, GKT136901 hydrochlor... | |||
T75815 | WKYMVM-NH2 TFA | ||
WKYMVM-NH2 TFA, a potent agonist for N-formyl peptide receptor (FPR1) and FPRL1/2, activates key leukocyte effector functions including chemotaxis, complement receptor-3 mobilization, and NADPH oxidase activation, as doc... | |||
T73896 | Glucose-6-phosphate dehydrogenase | ||
Glucose-6-phosphate dehydrogenase, the crucial rate-limiting enzyme in the pentose phosphate pathway, plays a vital role in generating NADPH. This compound is indispensable for numerous critical cellular functions such a... | |||
TP1948 | PBP10 | PBP 10 | |
Selective formyl peptide receptor 2 (FPR2) antagonist; cell permeable. Selectively inhibits FPR2-mediated NADPH oxidase activity but has no effect on FPR1 signaling in neutrophils. Displays PIP2 binding activity in vitro... | |||
T62004 | (Rac)-Nebivolol | ||
(Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective antagonist of β1-adrenergic receptor (IC 50= 0.8 nM). Nebivolol shows Vasodilatory activity. In the early stages of ethanol-ind... | |||
T63847 | 1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium | ||
Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium (18:1 Lyso-PS) is a modified PS product obtained through NADPH oxidase activation and Lyso-PS signal transduction. Oleoyl-2-hydroxy-sn-glycero-3phospho-L-serine sodiu... | |||
TP1891 | MMK 1 | ||
Potent and selective human formyl peptide receptor FPR2 agonist (EC50 values are 1, 2 and > 10 000 nM at mFRP2, hFPR2 and hFPR1 respectively). Induces migration of human monocytes and neutrophils via a chemotactic mechan... | |||
T71328 | Theobromine-d6 | ||
Theobromine-d6 is intended for use as an internal standard for the quantification of theobromine by GC- or LC-MS. Theobromine is a methylxanthine alkaloid and derivative of caffeine that has been found in cocoa beans and... | |||
T37583 | XTT (sodium salt hydrate) | ||
XTT is a cell-impermeable, negatively charged tetrazolium dye that produces a water-soluble formazan when reduced at the cell surface by cellular-derived NADH and an electron mediator.1,2It is frequently used in colorime... |
カタログ番号 | 製品名 | 別名 | ターゲット |
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T6391 | Apocynin | Acetovanillone,Acetoguaiacone,NSC 2146 | Apoptosis , NADPH , Autophagy |
Apocynin (NSC 2146) is a specific NADPH-oxidase inhibitor (IC50: 10 μM). | |||
TN2126 | Quercetin-3-O-glucose-6''-acetate | 6"-O-Acetylisoquercitrin | NADPH-oxidase , ROS , NADPH |
Quercetin-3-O-glucose-6''-acetate (6"-O-Acetylisoquercitrin) is an inhibitor of NADPH oxidase. Quercetin-3-O-glucose-6''-acetate has antioxidant activities. | |||
T5S2343 | Acetylshikonin | Acetyl shikonin | Others , P450 , AChE |
1. Acetylshikonin exhibits weak cytotoxicity against human umbilical vein endothelial cells (HUVECs) with IC5 of over 2 microM, exhibits the antiangiogenic and antitumorigenic effects by suppressing proliferation and ang... | |||
TN2039 | Panaxydol | cAMP , p38 MAPK , JNK | |
Panaxydol has anti-cancer activity, can inhibit the growth and apoptosis of cancer cells, the signaling mechanisms involve a [Ca(2+)](i) increase, JNK and p38 MAPK activation, cAMP, MAP kinase and ROS generation through ... | |||
TN6515 | Selaginellin | ||
Selaginellin has a neuroprotective effect against L-glutamate-induced neurotoxicity through mechanisms related to anti-oxidation and anti-apoptosis via scavenging reactive oxygen species and up-regulating the expression ... |
カタログ番号 | 製品名 | Species | Expression System |
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TMPJ-00848 | NCF1 Protein, Human, Recombinant (His) | Human | E. coli |
Neutrophil cytosol factor 1( NCF1) is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is characterized as a multicomponent enzyme which is activated to produce superoxide anion. NCF2, NCF1, and a mem... | |||
TMPH-03751 | CYBB Protein, Human, Recombinant (His) | Human | E. coli |
Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membr... | |||
TMPY-04475 | RFK Protein, Human, Recombinant (His) | Human | E. coli |
Flavokinase is a member of the transferases family, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. Flavokinase is an essential enzyme that catalyzes ... | |||
TMPY-02439 | Rac2 Protein, Human, Recombinant (His) | Human | E. coli |
Ras-related C3 botulinum toxin substrate 2 (Rac2) is a small G-protein belonging to the Ras subfamily of the GTPase family. Rac2 acts as an "on / off" switch for signal transduction cascades and motilities. When GDP is a... | |||
TMPY-01187 | Rac1 Protein, Human, Recombinant (GST) | Human | Baculovirus Insect Cells |
RAC1 is a GTPase that belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal re... |